Covalent docking-based virtual screening and molecular dynamics simulations identify C02b as a potential KRAS(G12C) inhibitor (2024), Tumor Discovery . [DOI]

SM. Bostancioglu, A. Acar

Patient-Derived Organoids: Past, Present, and Future  (2024), Interdisciplinary Cancer Research. [DOI]

A. Acar

Tumor Evolution Metrics Predict Recurrence beyond 10 Years in Locally Advanced Prostate Cancer (2024), Nature Cancer. [DOI]

J. Fernandez-Mateos, G. Cresswell, N. Trahearn, K. Webb, A. Lapmis, C. Stuttle, C. Corbishley, V. Starvrinides, L. Zapata, I. Spiteri, T.Heide, L. Gallagher, C. James, D. Ramazotti, A. Gao, Z. Kote-Jarai,  A. Acar, L. Truelove, P.  Proszek, J. Murray, A. Reid, A. Wilkins, M. Hubank, R. Eeles, D.  Dearnaley, A. Sottoriva

Exploiting Matrix Stiffness to Overcome Drug Resistance (2024), ACS Biomaterials Science & Engineering. [DOI]

Hakan Berk Aydin, Altug Ozcelikkale & Ahmet Acar

Optimizing Cancer Therapy: a Review of the Multifaceted Effects of Metronomic Chemotherapy (2024), Frontiers in Cell and Developmental Biology. [DOI]

Oyku Yagmur Basar, Sawsan Mohammed, M. Walid Qoronfleh & Ahmet Acar

Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture (2024), 3D Cell Culture. [DOI]

Hakan Berk Aydin, Hye-ran Moon, Bumsoo Han, Altug Ozcelikkale & Ahmet Acar

Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach (2024), Biomedicines. [DOI]

Subhamay Adhikary, Surajit Pathak, , Vignesh Palani, Ahmet Acar, Antara Banerjee, Nader I. Al-Dewik, Musthafa Mohamed Essa, Sawsan G. A. A. Mohammed & M. Walid Qoronfleh

Characterization of dabrafenib-induced drug insensitivity via cellular barcoding and collateral sensitivity to second-line therapeutics (2024), Scientific Reports. [DOI]

Rana Can Baygin, Kubra Celikbas Yilmaz, & Ahmet Acar

Investigation of evolutionary dynamics for drug resistance in 3D spheroid model system using cellular barcoding technology (2023), Plos One. [DOI]

Gizem Damla Yalcin, Kubra Celikbas Yilmaz, Tugce Dilber & Ahmet Acar

Identification of collateral sensitivity and evolutionary landscape of chemotheraphy-induced drug resistance using cellular barcoding technology (2023), Frontiers in Pharmacology. [DOI]

Nurseda Danisik, Kubra Celikbas Yilmaz & Ahmet Acar

Cancer Evolution (2023), Frontiers in Genetics. [DOI]

Luca Ermini, Diego Mallo, Dimitrios Kleftogiannis & Ahmet Acar

Pan-cancer analysis of the COVID-19 causal gene SCL6A20(2023)ACS Omega [DOI]

Ahmet Acar

Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors (2023), Nature Genetics. [DOI]

Luis Zapata, Giulio Caravagna, Marc J. Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore Milite, Ahmet Acar, Nadeem Riaz, Timothy A. Chan, Trevor A. Graham & Andrea Sottoriva

Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers (2022), Scientific Reports. [DOI]

Mehmet Arda Temena, Ahmet Acar

Inhibition of Wnt signalling by Notch via two distinct mechanisms(2021), Scientific Reports. [DOI]

Ahmet Acar, Ana Hidalgo-Sastre, Michael Karl Leverentz, Christopher Mills, Simon Woodcock, Martin Baron, Giovanna Collu, Keith Brennan

Systems Biology and Experimental Model Systems of Cancer(2020), Journal of Personalized Medicine. [DOI]

Gizem Damla Yalcin, Nurseda Danisik, Rana Can Baygin, Ahmet Acar

Subclonal reconstruction of tumors by using machine learning and population genetics(2020), Nature Genetics. [DOI]

Giulio Caravagna, Timon Heide, Marc J Williams, Luis Zapata, Daniel Nichol, Ketevan Chkhaidze, William Cross, George D Cresswell, Benjamin Werner, Ahmet Acar, Louis Chesler, Chris P Barnes, Guido Sanguinetti, Trevor A Graham, Andrea Sottoriva

Exploiting evolutionary steering to induce collateral drug sensitivity in cancer(2020), Nature Communications. [DOI]

Ahmet Acar, Daniel Nichol, Javier Fernandez-Mateos, George D Cresswell, Iros Barozzi, Sung Pil Hong, Nicholas Trahearn, Inmaculada Spiteri, Mark Stubbs, Rosemary Burke, Adam Stewart, Giulio Caravagna, Benjamin Werner, Georgios Vlachogiannis, Carlo C Maley, Luca Magnani, Nicola Valeri, Udai Banerji, Andrea Sottoriva

Evolutionary dynamics of residual disease in human glioblastoma(2019), Annals of Oncology. [DOI]

Inma Spiteri, Giulio Caravagna, GD Cresswell, A Vatsiou, D Nichol, Ahmet Acar, L Ermini, K Chkhaidze, B Werner, R Mair, E Brognaro, Roel GW Verhaak, G Sanguinetti, SGM Piccirillo, C Watts, A Sottoriva

The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer(2018), Clinical Cancer Research. [DOI]

Peter Barry, Alexandra Vatsiou, Inmaculada Spiteri, Daniel Nichol, George D Cresswell, Ahmet Acar, Nicholas Trahearn, Sarah Hrebien, Isaac Garcia-Murillas, Kate Chkhaidze, Luca Ermini, Ian Said Huntingford, Hannah Cottom, Lila Zabaglo, Konrad Koelble, Saira Khalique, Jennifer E Rusby, Francesca Muscara, Mitch Dowsett, Carlo C Maley, Rachael Natrajan, Yinyin Yuan, Gaia Schiavon, Nicholas Turner, Andrea Sottoriva

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance(2016), Stem Cells International. [DOI]

Ahmet Acar, Bruno M Simões, Robert B Clarke, Keith Brennan

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity(2015), Cell Reports. [DOI]

Bruno M Simões, Ciara S O’Brien, Rachel Eyre, Andreia Silva, Ling Yu, Aida Sarmiento-Castro, Denis G Alférez, Kath Spence, Angélica Santiago-Gómez, Francesca Chemi, Ahmet Acar, Ashu Gandhi, Anthony Howell, Keith Brennan, Lisa Rydén, Stefania Catalano, Sebastiano Andó, Julia Gee, Ahmet Ucar, Andrew H Sims, Elisabetta Marangoni, Gillian Farnie, Göran Landberg, Sacha J Howell, Robert B Clarke

Notch: evidence for combining therapies to treat breast cancer(2013), Breast Cancer Management. [DOI]

Michael K Leverentz, Ahmet Acar, Keith Brennan

TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer(2013), Oncogene. [DOI]

S Busch, A Acar, Y Magnusson, P Gregersson, Lisa Rydén, G Landberg

Dishevelled limits Notch signalling through inhibition of CSL(2012), Development. [DOI]

Giovanna M Collu, Ana Hidalgo-Sastre, Ahmet Acar, Laura Bayston, Clara Gildea, Michael K Leverentz, Christopher G Mills, Thomas W Owens, Olivier Meurette, Karel Dorey, Keith Brennan

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts(2011), JoVE. [DOI]

Urszula M Polanska, Ahmet Acar, Akira Orimo